Clone A16085H
Regulatory Status RUO
Other Names VEGFR2, KDR
Isotype Mouse IgG1, κ
Description CD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane
glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase
2025-05-19receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.
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